Article
An HLA-DRB alpha-helix motif shared by DR11 and DR8 alleles is implicated in the pluriallelic restriction of peptide-specific T-cell lines.
Human immunology - 1 Aug 1994
Martínez-Soria E, Steimle V, Burkhardt C, Beffy P, Tiercy J M, Epplen J T, Mach B, Irlé C
Abstract excerpt
The T-cell recognition of HLA-DR-peptide complexes is generally restricted by the polymorphism of the DRB molecules but pluriallelic restriction has been described. The molecular basis of restriction and promiscuity of such peptide-specific responses is poorly understood. We isolated a panel of T...
Topics
- Alleles
- Amino Acid Sequence
- Antibodies, Monoclonal
- Cell Line
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- HLA-DRB1 Chains
- Humans
- Lymphocyte Activation
- Molecular Sequence Data
- Protein Structure, Secondary
- T-Lymphocytes