Article
Towards prediction of degenerate CTL epitope recognition.
Human vaccines - 1 Jan 2000
Li Fusheng, McKenney Denise M, Malhotra Uma, Crimi Claire, Nolin Jessica, Corey Lawrence, McElrath Juliana M, Newman Mark J, Self Steven G
Abstract excerpt
The cellular immune system is characterized by flexibility with respect to epitope recognition at the level of peptide binding to HLA molecules and HLA-peptide complexes to T-cell receptors (TCRs). For epitopes recognized by cytotoxic T-lymphocytes (CTLs), amino acid substitutions at different positions have varying impact on recognition. By analyzing the frequencies of specific amino acid substitutions at each...
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