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Article

Immune recognition of transplacentally acquired lymphoid allografts selects for increased major histocompatibility polymorphism.

Medical hypotheses - 1 Sept 2011

Naugler Christopher

Abstract excerpt

The extreme polymorphism of mammalian major histocompatibility (MHC) Class I and Class II alleles has been attributed to inbreeding avoidance, heterozygote advantage and pathogen driven selection for rare MHC alleles. However, MHC alleles can be classified into a limited number of allele supertypes based on the specificity of their peptide binding grooves (about 10 supertypes in the case of human MHC Class I...

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Source

Identifiers

PMID: 21605938
DOI: 10.1016/j.mehy.2011.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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