Article
Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility.
American journal of human genetics - 1 Dec 1998
Chapman N H, Wijsman E M
Abstract excerpt
Linkage disequilibrium (LD) testing has become a popular and effective method of fine-scale disease-gene localization. It has been proposed that LD testing could also be used for genome screening, particularly as dense maps of diallelic markers become available and automation allows inexpensive g...
Topics
- Alleles
- Case-Control Studies
- Gene Frequency
- Genes, Dominant
- Genes, Recessive
- Genetic Diseases, Inborn
- Genetic Markers
- Genetic Testing
- Genetics, Population
- Genome, Human
- Genotype
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Sample Size
- Sensitivity and Specificity
- Time Factors