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Article

Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility.

American journal of human genetics - 1 Dec 1998

Chapman N H, Wijsman E M

Abstract excerpt

Linkage disequilibrium (LD) testing has become a popular and effective method of fine-scale disease-gene localization. It has been proposed that LD testing could also be used for genome screening, particularly as dense maps of diallelic markers become available and automation allows inexpensive genotyping of diallelic markers. We compare diallelic markers and multiallelic markers in terms of sample sizes required...

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Identifiers

PMID: 9837839
DOI: 10.1086/302139
PMCID: PMC1377658

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