Article
Cost-effective designs for linkage disequilibrium mapping of complex traits.
American journal of human genetics - 1 May 2003
Service Susan K, Sandkuijl Lodewijk A, Freimer Nelson B
Abstract excerpt
The current development of densely spaced collections of single nucleotide polymorphisms (SNPs) will lead to genomewide association studies for a wide range of diseases in many different populations. Determinations of the appropriate number of SNPs to genotype involve a balancing of power and cost. Several variables are important in these determinations. We show that there are different combinations of sample...
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