Article
Population choice in mapping genes for complex diseases.
Nature genetics - 1 Dec 1999
Wright A F, Carothers A D, Pirastu M
Abstract excerpt
The difficulty of identifying susceptibility genes for common diseases has polarized geneticists' views on what disease models are appropriate and how best to proceed once high-density genome maps become available. Different disease models have different implications for using linkage or linkage-disequilibrium-based approaches for mapping complex disease genes. We argue that the choice of study population is a...
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