Association mapping of complex diseases with ancestral recombination graphs: models and efficient algorithms.

Abstract excerpt

Association, or linkage disequilibrium (LD), mapping is an intensely studied approach to gene mapping (genome-wide or in candidate regions) that is widely hoped to be able to efficiently locate genes influencing both complex and Mendelian traits. The logic underlying association mapping implies that the best possible mapping results would be obtained if the genealogical history of the sampled individuals were...

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