Article
acrB mutation located at carboxyl-terminal region of gyrase B subunit reduces DNA binding of DNA gyrase.
The Journal of biological chemistry - 16 May 1997
Funatsuki K, Tanaka R, Inagaki S, Konno H, Katoh K, Nakamura H
Abstract excerpt
Mutations that exhibit susceptibility to acriflavine have been isolated and classified as acr mutations in Escherichia coli. We cloned the acrB gene, which has been identified as a mutation of the gyrB gene, and found a double point mutation altering two consecutive amino acids (S759R/R760C) in the COOH-terminal region of the gyrase B subunit. The mutant B subunit was found to associate with the A subunit to make...
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