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Article

Role of a conserved residue R780 in Escherichia coli multidrug transporter AcrB.

Biochemistry - 1 Oct 2013

Yu Linliang, Lu Wei, Ye Cui, Wang Zhaoshuai, Zhong Meng, Chai Qian, Sheetz Michael, Wei Yinan

Abstract excerpt

Multidrug efflux pumps play important roles in bacteria drug resistance. A major multidrug efflux system in Gram-negative bacteria is composed of the inner membrane transporter AcrB, outer membrane protein channel TolC, and membrane fusion protein AcrA. These three proteins form a large complex that spans both layers of cell membranes and the periplasmic space. AcrB exists and functions as a homotrimer. To...

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PMID: 24007302
DOI: 10.1021/bi400452v

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