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Article

Analysis of the impact of a uracil DNA glycosylase attenuated in AP-DNA binding in maintenance of the genomic integrity in Escherichia coli.

Nucleic acids research - 1 Apr 2010

Bharti Sanjay Kumar, Varshney Umesh

Abstract excerpt

Uracil DNA glycosylase (Ung) initiates the uracil excision repair pathway. We have earlier characterized the Y66W and Y66H mutants of Ung and shown that they are compromised by approximately 7- and approximately 170-fold, respectively in their uracil excision activities. In this study, fluorescence anisotropy measurements show that compared with the wild-type, the Y66W protein is moderately compromised and...

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Identifiers

PMID: 20056657
DOI: 10.1093/nar/gkp1210
PMCID: PMC2853124

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