gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

doi:10.1111/j.1365-2958.1992.tb00886.x

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Article

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

Molecular microbiology - 1 Jun 1992

Contreras A, Maxwell A

Abstract excerpt

Coumarins are inhibitors of the ATP hydrolysis and DNA supercoiling reactions catalysed by DNA gyrase. Their target is the B subunit of gyrase (GyrB), encoded by the gyrB gene. The exact mode and site of action of the drugs is unknown. We have identified four mutations conferring coumarin resista...

Topics

Adenosine Triphosphate
Bacterial Proteins
Base Sequence
Coumarins
DNA Topoisomerases, Type II
DNA, Bacterial
DNA, Superhelical
Drug Resistance, Microbial
Escherichia coli
Genes, Bacterial
Hydrolysis
Molecular Sequence Data
Mutation

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