Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

Molecular microbiology - 1 Jun 1992

Contreras A, Maxwell A

Abstract excerpt

Coumarins are inhibitors of the ATP hydrolysis and DNA supercoiling reactions catalysed by DNA gyrase. Their target is the B subunit of gyrase (GyrB), encoded by the gyrB gene. The exact mode and site of action of the drugs is unknown. We have identified four mutations conferring coumarin resistance to Escherichia coli: Arg-136 to Cys, His or Ser and Gly-164 to Val. In vitro, the ATPase and supercoiling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Escherichia coli

Share to Genes, Bacterial

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 1323022
DOI: 10.1111/j.1365-2958.1992.tb00886.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.PMID 1323022Read ↗

gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity.Semantic proximity Read ↗

Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.Semantic proximity Read ↗

Quinolone-binding pocket of DNA gyrase: role of GyrB.Semantic proximity Read ↗

Alteration of Escherichia coli topoisomerase IV to novobiocin resistance.Semantic proximity Read ↗

Mutations in Bartonella bacilliformis gyrB confer resistance to coumermycin A1.Semantic proximity Read ↗

Biological activities of novel gyrase inhibitors of the aminocoumarin class.Semantic proximity Read ↗

Mutations in topoisomerase IV and DNA gyrase of Staphylococcus aureus: novel pleiotropic effects on quinolone and coumarin activity.Semantic proximity Read ↗

Coumarin‐containing hybrids and their antibacterial activitiesSemantic proximity Read ↗

Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology.Semantic proximity Read ↗

Identification of a topoisomerase IV in actinobacteria: purification and characterization of ParYR and GyrBR from the coumermycin A1 producer Streptomyces rishiriensis DSM 40489.Semantic proximity Read ↗

Topoisomerase IV is a target of quinolones in Escherichia coli.Semantic proximity Read ↗

The "GyrA-box" is required for the ability of DNA gyrase to wrap DNA and catalyze the supercoiling reaction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.