Article
Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland.
American journal of medical genetics - 16 Apr 1999
McIlroy S P, Vahidassr M D, Savage D A, Patterson C C, Lawson J T, Passmore A P
Abstract excerpt
The epsilon-4 allele of apolipoprotein E (APOE) is associated with increased risk of Alzheimer's disease (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5' untranslated region of the very low-density lipoprotein receptor (VLDL-R) gene, a receptor for apoE, has been found to be associated with increased risk of AD in a Japanese population. Other groups have...
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