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Article

Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997

Okamoto K, Morison I M, Taniguchi T, Reeve A E

Abstract excerpt

Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in the onset of sporadic Wilms tumor and several other embryonal tumors. The high prevalence of histologically abnormal foci in kidney adjacent to Wilms tumors suggests that tumor-predisposing genetic/epigenetic lesion might also be found at high frequency in Wilms tumor-bearing kidneys. Focusing on...

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Identifiers

PMID: 9144243
DOI: 10.1073/pnas.94.10.5367
PMCID: PMC24684

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Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.PMID 9144243Read ↗

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