Article
Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997
Okamoto K, Morison I M, Taniguchi T, Reeve A E
Abstract excerpt
Relaxation of imprinting at the insulin-like growth factor II (IFG-II)/H19 locus is a major mechanism involved in the onset of sporadic Wilms tumor and several other embryonal tumors. The high prevalence of histologically abnormal foci in kidney adjacent to Wilms tumors suggests that tumor-predis...
Topics
- Alleles
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- DNA
- DNA Methylation
- DNA Probes
- Disease Susceptibility
- Genes, Tumor Suppressor
- Genomic Imprinting
- Humans
- Insulin-Like Growth Factor II
- Kidney
- Kidney Neoplasms
- Mosaicism
- Muscle Proteins
- Promoter Regions, Genetic
- RNA, Long Noncoding