Article
Embryonal precursors of Wilms tumor.
Science (New York, N.Y.) - 6 Dec 2019
Coorens Tim H H, Treger Taryn D, Al-Saadi Reem, Moore Luiza, Tran Maxine G B, Mitchell Thomas J, Tugnait Suzanne, Thevanesan Christine, Young Matthew D, Oliver Thomas R W, Oostveen Minou, Collord Grace, Tarpey Patrick S, Cagan Alex, Hooks Yvette, Brougham Mark, Reynolds Ben C, Barone Giuseppe, Anderson John, Jorgensen Mette, Burke G A Amos, Visser Johannes, Nicholson James C, Smeulders Naima, Mushtaq Imran, Stewart Grant D, Campbell Peter J, Wedge David C, Martincorena Iñigo, Rampling Dyanne, Hook Liz, Warren Anne Y, Coleman Nicholas, Chowdhury Tanzina, Sebire Neil, Drost Jarno, Saeb-Parsy Kourosh, Stratton Michael R, Straathof Karin, Pritchard-Jones Kathy, Behjati Sam
Abstract excerpt
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in...
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