Article
Mosaic allelic insulin-like growth factor 2 expression patterns reveal a link between Wilms' tumorigenesis and epigenetic heterogeneity.
Cancer research - 15 Aug 1999
Ohlsson R, Cui H, He L, Pfeifer S, Malmikumpu H, Jiang S, Feinberg A P, Hedborg F
Abstract excerpt
Numerous observations link the loss of imprinting of insulin-like growth factor 2 (IGF2) and an overdosage of this growth factor gene with cancer, in general, and with Wilms' tumorigenesis, in particular. It is not known, however, if loss of imprinting correlates with specific stages of neoplasia or if allelic expression patterns vary within the tumor. By applying an allele-specific in situ hybridization...
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