Protection of<i>Mycobacterium tuberculosis</i>from Reactive Oxygen Species Conferred by the<i>mel2</i>Locus Impacts Persistence and Dissemination

Abstract excerpt

Persistence of Mycobacterium tuberculosis in humans represents a major roadblock to elimination of tuberculosis. We describe identification of a locus in M. tuberculosis, mel2, that displays similarity to bacterial bioluminescent loci and plays an important role during persistence in mice. We constructed a deletion of the mel2 locus and found that the mutant displays increased susceptibility to reactive oxygen...

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