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Article

What is the Role of Nitric Oxide in Murine and Human Host Defense against Tuberculosis?

1 Nov 2001

Abstract excerpt

The production of reactive oxygen intermediates and reactive nitrogen intermediates by innate immune cells is considered to be an effective host-defense mechanism against microbial pathogens. In the murine model of tuberculosis (TB), nitric oxide (NO) plays an essential role in the killing of Mycobacterium tuberculosis by mononuclear phagocytes. For example, in the mouse strain with a genetic disruption for...

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PMID: 11713103
DOI: 10.1165/ajrcmb.25.5.4487

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