Article
Combination of host susceptibility and Mycobacterium tuberculosis virulence define gene expression profile in the host.
European journal of immunology - 1 Dec 2009
Beisiegel Martin, Mollenkopf Hans-Joachim, Hahnke Karin, Koch Markus, Dietrich Isabell, Reece Stephen T, Kaufmann Stefan H E
Abstract excerpt
Progression and outcome of tuberculosis is governed by extensive crosstalk between pathogen and host. Analyses of global changes in gene expression during immune response to infection with Mycobacterium tuberculosis (M.tb) can help identify molecular markers of disease state and progression. Global distribution of M.tb strains with different degrees of virulence and drug resistance, especially for the...
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