Article
Polymorphisms in the prostaglandin receptor EP2 gene confers susceptibility to tuberculosis.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2016
Liang Li, Zhang Qing, Luo Liu-Lin, Yue Jun, Zhao Yan-Lin, Han Min, Liu Li-Rong, Xiao He-Ping
Abstract excerpt
OBJECTIVES: Prostaglandin E2 (PGE2) is an important lipid mediator of the inflammatory immune response during acute and chronic infections. PGE2 modulates a variety of immune functions via four receptors (EP1-EP4), which mediate distinct PGE2 effects. Mice lacking EP2 are more susceptible to infection by Mycobacterium tuberculosis (M.tb), have a higher bacterial load, and increase size and number of granulomatous...
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