Article
A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis.
Mucosal immunology - 1 Nov 2018
Dunlap Micah D, Howard Nicole, Das Shibali, Scott Ninecia, Ahmed Mushtaq, Prince Oliver, Rangel-Moreno Javier, Rosa Bruce A, Martin John, Kaushal Deepak, Kaplan Gilla, Mitreva Makedonka, Kim Ki-Wook, Randolph Gwendalyn J, Khader Shabaana A
Abstract excerpt
C-C motif chemokine receptor 2 (CCR2) is a major chemokine axis that recruits myeloid cells including monocytes and macrophages. Thus far, CCR2-/- mice have not been found to be susceptible to infection with Mycobacterium tuberculosis (Mtb). Here, using a prototype W-Beijing family lineage 2 Mtb strain, HN878, we show that CCR2-/- mice exhibit increased susceptibility to tuberculosis (TB). Following exposure to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.