Article
Protection of primary human T cells from HIV infection by Trev: a transdominant fusion gene.
Human gene therapy - 1 May 1997
Chinen J, Aguilar-Cordova E, Ng-Tang D, Lewis D E, Belmont J W
Abstract excerpt
Gene therapy is one of several approaches that are being tested in the search for an effective anti-human immunodeficiency virus (HIV) treatment. In this strategy, a "protective" gene would be introduced into target cells, rendering them relatively resistance to the virus-induced cytopathicity. Tat and Rev are viral proteins essential for HIV gene expression. Tat increases viral gene transcription and Rev is...
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