Article
A molecular, clinical, and immunohistochemical study of vestibular schwannoma.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Apr 1997
Irving R M, Moffat D A, Hardy D G, Barton D E, Xuereb J H, Holland F J, Maher E R
Abstract excerpt
The molecular pathogenesis of vestibular schwannoma has been investigated by determining the extent of chromosome 22 loss of heterozygosity in 77 tumors and relating these findings to clinical and immunohistochemical indexes of tumor behavior. Loss of heterozygosity was looked for at eight chromo...
Topics
- Adult
- Aged
- Alleles
- Antibodies, Monoclonal
- Cell Division
- Chromosome Deletion
- Chromosome Mapping
- Chromosomes, Human, Pair 22
- Ear Neoplasms
- Female
- Gene Expression Regulation, Neoplastic
- Genes, Neurofibromatosis 2
- Heterozygote
- Humans
- Immunohistochemistry
- Male
- Microsatellite Repeats
- Middle Aged