Clinical manifestations of mutations in the neurofibromatosis type 2 gene in vestibular schwannomas (acoustic neuromas).

doi:10.1097/00005537-199802000-00005

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Article

Clinical manifestations of mutations in the neurofibromatosis type 2 gene in vestibular schwannomas (acoustic neuromas).

The Laryngoscope - 1 Feb 1998

Welling D B

Abstract excerpt

Vestibular schwannomas (acoustic neuromas) continue to cause significant facial nerve and hearing morbidity, despite marked improvement in diagnosis and treatment. Mutation of a tumor-suppressor gene on human chromosome 22 has been found to be associated with vestibular schwannoma formation. The...

Topics

Adult
Aged
Chromosomes, Human, Pair 22
Female
Genes, Neurofibromatosis 2
Genetic Testing
Humans
Male
Membrane Proteins
Middle Aged
Mutation
Neurofibromatosis 2
Neurofibromin 2
Pedigree
Phenotype
Polymerase Chain Reaction
Sequence Analysis, DNA

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