Article
Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha.
Science (New York, N.Y.) - 9 May 1997
Hériché J K, Lebrin F, Rabilloud T, Leroy D, Chambaz E M, Goldberg Y
Abstract excerpt
Timely deactivation of kinase cascades is crucial to the normal control of cell signaling and is partly accomplished by protein phosphatase 2A (PP2A). The catalytic (alpha) subunit of the serine-threonine kinase casein kinase 2 (CK2) bound to PP2A in vitro and in mitogen-starved cells; binding required the integrity of a sequence motif common to CK2alpha and SV40 small t antigen. Overexpression of CK2alpha...
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