Article
Regulatory role of CK2 during the progression of cell cycle.
Molecular and cellular biochemistry - 1 Jun 2005
Homma Miwako Kato, Homma Yoshimi
Abstract excerpt
The protein kinase casein kinase 2 (CK2) is a ubiquitous eukaryotic serine/threonine protein kinase that plays an important role in cell cycle progression. We find that (1) CK2 interacts with a tumor suppressor protein, adenomatous polyposis coli (APC) that occurs at the highest level in G2/M, and (2) the C-terminal region of APC, between amino acid residues 2086-2394, has the strongest activity to suppress CK2....
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