Article
CK2 as a positive regulator of Wnt signalling and tumourigenesis.
Molecular and cellular biochemistry - 1 Jun 2005
Seldin David C, Landesman-Bollag Esther, Farago Marganit, Currier Nicolas, Lou David, Dominguez Isabel
Abstract excerpt
CK2 is upregulated in rapidly dividing cells including most human tumours. Transgenic overexpression of CK2 in lymphoid or mammary lineages predisposes to transformation. Multiple signalling and oncogene pathways could be regulated by CK2 in this process. Our studies suggest that phosphorylation of critical oncogenes by CK2, as well as by other serine-threonine kinases, regulates their stability via...
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