Article
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity.
The Biochemical journal - 15 Jun 2003
Donella-Deana Arianna, Cesaro Luca, Sarno Stefania, Ruzzene Maria, Brunati Anna Maria, Marin Oriano, Vilk Greg, Doherty-Kirby Amanda, Lajoie Gilles, Litchfield David W, Pinna Lorenzo A
Abstract excerpt
Casein kinase-2 (CK2) is a pleiotropic and constitutively active serine/threonine protein kinase composed of two catalytic (alpha and/or alpha') and two regulatory beta-subunits, whose regulation is still not well understood. In the present study, we show that the catalytic subunits of human CK2, but not the regulatory beta-subunits, are readily phosphorylated by the Src family protein tyrosine kinases Lyn and...
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