Limited junctional diversity of V delta 5-J delta 1 rearrangement in multiple sclerosis patients.

doi:10.1007/BF02815152

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Article

Limited junctional diversity of V delta 5-J delta 1 rearrangement in multiple sclerosis patients.

Molecular and chemical neuropathology - 1 Jan 2000

Nowak J S, Michałowska-Wender G, Januszkiewicz D, Wender M

Abstract excerpt

T-cell receptor (TCR) delta gene repertoire, as assessed by V delta-J delta rearrangements, has been analyzed in nine multiple sclerosis (MS) cases and in 30 healthy individuals by seminested PCR technique. Among the V delta-J delta junctional diversities studied, the most striking result has bee...

Topics

Adult
Base Sequence
DNA Primers
Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
Genetic Variation
Humans
Lymphocytes
Middle Aged
Multiple Sclerosis
Polymerase Chain Reaction
Reference Values

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