Article
Limited junctional diversity of V delta 5-J delta 1 rearrangement in multiple sclerosis patients.
Molecular and chemical neuropathology - 1 Jan 2000
Nowak J S, Michałowska-Wender G, Januszkiewicz D, Wender M
Abstract excerpt
T-cell receptor (TCR) delta gene repertoire, as assessed by V delta-J delta rearrangements, has been analyzed in nine multiple sclerosis (MS) cases and in 30 healthy individuals by seminested PCR technique. Among the V delta-J delta junctional diversities studied, the most striking result has been observed in V delta 5-J delta 1 rearrangement. The detection of repeated V delta 5-J delta 1 nucleotide sequences in...
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