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Article

Clonal expansion and somatic hypermutation of V(H) genes of B cells from cerebrospinal fluid in multiple sclerosis.

The Journal of clinical investigation - 1 Sept 1998

Qin Y, Duquette P, Zhang Y, Talbot P, Poole R, Antel J

Abstract excerpt

The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by increased concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows restricted heterogeneity (oligoclonal bands). CSF Ig is composed of both serum and intrathecally produced components. To examine the properties of intrathecal antibody-producing B cells, we analyzed Ig heavy-chain variable (V(H)) region...

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Identifiers

PMID: 9727074
DOI: 10.1172/JCI3568
PMCID: PMC508971

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