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Article

Accumulation of clonally related B lymphocytes in the cerebrospinal fluid of multiple sclerosis patients.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2000

Colombo M, Dono M, Gazzola P, Roncella S, Valetto A, Chiorazzi N, Mancardi G L, Ferrarini M

Abstract excerpt

The accumulation of B lymphocyte clones in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and patients with other neurological disorders was investigated using PCR technologies. Oligoclonal B cell accumulations were detected in 10 of 10 MS patients, but only in 3 of 10 of the patients with other neurological disorders. Analyses of the Ig V(D)J sequences on the CSF from MS patients...

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Source

Identifiers

PMID: 10679121
DOI: 10.4049/jimmunol.164.5.2782

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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