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Article

Peripheral expression of Jak3 is required to maintain T lymphocyte function.

The Journal of experimental medicine - 20 Jan 1997

Thomis D C, Berg L J

Abstract excerpt

The Jak family tyrosine kinase, Jak3, is involved in signaling through cytokine receptors that utilize the common gamma chain (gammac), such as those for IL-2, IL-4, IL-7, IL-9, and IL-15. Recent studies of Jak3-deficient mice and humans have demonstrated that Jak3 plays a critical role in B and...

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Identifiers

PMID: 9016869
DOI: 10.1084/jem.185.2.197
PMCID: PMC2196115

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9016869-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Peripheral expression of Jak3 is required to maintain T lymphocyte function.PMID 9016869Read ↗

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Jak3 and the pathogenesis of severe combined immunodeficiency.Semantic proximity Read ↗

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Stat5a/b are essential for normal lymphoid development and differentiation.Semantic proximity Read ↗

Janus kinases in immune cell signalingSemantic proximity Read ↗

Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation.Semantic proximity Read ↗

The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signalsSemantic proximity Read ↗

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.Semantic proximity Read ↗

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