Defective lymphoid development in mice lacking Jak3.

doi:10.1126/science.270.5237.800

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Article

Defective lymphoid development in mice lacking Jak3.

Science (New York, N.Y.) - 3 Nov 1995

Nosaka T, van Deursen J M, Tripp R A, Thierfelder W E, Witthuhn B A, McMickle A P, Doherty P C, Grosveld G C, Ihle J N

Abstract excerpt

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common gamma (gamma c) chain of the interleukin (IL)-2,...

Topics

Aging
Animals
Antigens, CD
B-Lymphocytes
Chimera
Female
Gene Targeting
Interleukin-7
Janus Kinase 3
Lymphocyte Activation
Lymphocyte Count
Lymphocyte Subsets
Lymphoid Tissue
Male
Mice
Mice, Inbred C57BL
Phenotype
Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 7481769
DOI: 10.1126/science.270.5237.800

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7481769-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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