Article
Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2001
Hsu P N, Wolf Bryant P, Sutkowski N, McLellan B, Ploegh H L, Huber B T
Abstract excerpt
Mouse mammary tumor viruses encode superantigens that interact with MHC class II proteins and stimulate T cells. We show here that presentation of mouse mammary tumor virus superantigen does not require DM. Furthermore, we have identified a strong class II peptide binding motif in the Mtv-7 superantigen, and we show that this motif is necessary for association with class II molecules in in vitro translation and...
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