Article
The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.
Brain pathology (Zurich, Switzerland) - 1 Jan 2001
Campagnoni A T, Skoff R P
Abstract excerpt
Substantial biological data indicate that the myelin basic protein (MBP) and myelin proteolipid protein (PLP/DM20) genes produce products with functions beyond that of serving as myelin structural proteins. Much of this evidence comes from studies on naturally-occurring and man-made mutations of these genes in mice and other species. This review focuses upon recent evidence showing the existence of other products...
Topics
- Amino Acid Sequence
- Animals
- Cell Communication
- Gene Expression
- Humans
- Mutation
- Myelin Basic Protein
- Myelin Proteolipid Protein
- Myelin Sheath
- Oligodendroglia
- Protein Conformation