Generation and analysis of normal and shiverer temperature-sensitive immortalized cell lines exhibiting phenotypic characteristics of oligodendrocytes at several stages of differentiation.

Abstract excerpt

Normal glial cells immortalized at specific developmental stages would be useful tools with which to study glial cell differentiation in vitro. Similarly, immortalized glial cell lines derived from known neurological mutants with identified developmental, molecular genetic defects would also be u...

Topics

• Animals
• Antibodies, Monoclonal
• Blotting, Northern
• Blotting, Southern
• Cell Differentiation
• Cell Line
• Gene Expression
• Immunohistochemistry
• Intermediate Filaments
• Mice
• Mice, Neurologic Mutants