Article
Analysis of alpha-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia.
American journal of medical genetics - 18 Apr 1997
Tysoe C, Galinsky D, Robinson D, Brayne C E, Easton D F, Huppert F A, Dening T, Paykel E S, Rubinsztein D C
Abstract excerpt
The genetic factors which predispose individuals to dementia in old age have not been fully defined. Although the apolipoprotein E4 allele accounts for a proportion of the genetic risk for late-onset Alzheimer disease (AD), it is neither necessary nor sufficient to cause this disease. Recent suggestions that other loci are involved in dementia risk have been supported by findings of associations of genotypes at...
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