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Article

ApoE genotype does not affect plasma tPA and PAI-1 antigen levels.

American journal of medical genetics - 18 Apr 1997

Mermod J J, Kruithof E K, Alouani S, Quiquerez A L, Sadoul R

Abstract excerpt

The presence of one or two apoliprotein E4 (apoE4) alleles constitutes a major risk factor for Alzheimer's disease (AD) and coronary heart disease (CHD). Numerous observations have suggested that misregulation of proteases may be instrumental in both diseases. Tissue-type plasminogen activator (tPA) has been recently demonstrated to play a key role in neuronal plasticity and in experimental neurodegeneration. One...

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PMID: 9129718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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