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Article

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.

Antimicrobial agents and chemotherapy - 1 Dec 1996

Janoir C, Zeller V, Kitzis M D, Moreau N J, Gutmann L

Abstract excerpt

The mechanism of high-level fluoroquinolone resistance was studied in strains of Streptococcus pneumoniae, either selected in vitro or isolated from clinical samples. By using DNA from these high-level-resistant strains, low-level-resistant transformants (MIC of pefloxacin, > or = 32 micrograms/ml; MIC of ciprofloxacin, 4 micrograms/ml; MIC of sparfloxacin, 0.50 micrograms/ml) were obtained at high frequencies...

Topics

4-Quinolones
Anti-Infective Agents
Ciprofloxacin
DNA Gyrase
DNA Topoisomerase IV
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Fluoroquinolones
Genes, Bacterial
Mutation
Quinolones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Streptococcus pneumoniae

Transformation, Genetic

Pefloxacin

Source

Open in PubMed Open full text

Identifiers

PMID: 9124836
DOI: 10.1128/AAC.40.12.2760
PMCID: PMC163617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9124836-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.PMID 9124836Read ↗

Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro.Semantic proximity Read ↗

Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes.Semantic proximity Read ↗

ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype.Semantic proximity Read ↗

ParC and GyrA may be interchangeable initial targets of some fluoroquinolones in Streptococcus pneumoniae.Semantic proximity Read ↗

Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniaeSemantic proximity Read ↗

Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance.Semantic proximity Read ↗

Fluoroquinolone resistance in Streptococcus pneumoniae: evidence that gyrA mutations arise at a lower rate and that mutation in gyrA or parC predisposes to further mutation.Semantic proximity Read ↗

Analysis of the mutations involved in fluoroquinolone resistance of in vivo and in vitro mutants of Escherichia coli.Semantic proximity Read ↗

Genomic characterization of ciprofloxacin resistance in a laboratory-derived mutant and a clinical isolate of Streptococcus pneumoniae.Semantic proximity Read ↗

Low-level resistance to rifampin in Streptococcus pneumoniae.Semantic proximity Read ↗

Resistance to Multiple Fluoroquinolones in a Clinical Isolate of Streptococcus pyogenes : Identification of gyrA and parC and Specification of Point Mutations Associated with ResistanceSemantic proximity Read ↗

Combination of known and unknown mechanisms confers high-level resistance to fluoroquinolones in Enterococcus faecium.Semantic proximity Read ↗

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