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Article

Analysis of the mutations involved in fluoroquinolone resistance of in vivo and in vitro mutants of Escherichia coli.

Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1998

Bachoual R, Tankovic J, Soussy C J

Abstract excerpt

We searched for the mutations involved in high-level fluoroquinolone resistance (ciprofloxacin MIC > or = 8 microg/ml) of 11 clinical isolates of Escherichia coli. trans-Complementation tests with the wild-type gyrA and parC genes were positive for all strains whereas negative results were observed with the wild-type gyrB and parE genes. By PCR and sequencing, two mutations in gyrA, leading to Ser-83 --> Leu and...

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Identifiers

PMID: 9988045
DOI: 10.1089/mdr.1998.4.271

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