Article
Sparfloxacin resistance in clinical isolates of Streptococcus pneumoniae: involvement of multiple mutations in gyrA and parC genes.
Antimicrobial agents and chemotherapy - 1 Sept 1998
Taba H, Kusano N
Abstract excerpt
Antimicrobial susceptibility testing revealed among 150 clinical isolates of Streptococcus pneumoniae 4 pneumococcal isolates with resistance to fluoroquinolones (MIC of ciprofloxacin, >/=32 microgram/ml; MIC of sparfloxacin, >/=16 microgram/ml). Gene amplification and sequencing analysis of gyrA...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Quinolones
- Streptococcus pneumoniae