Article
Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro.
Antimicrobial agents and chemotherapy - 1 Nov 1996
Tankovic J, Perichon B, Duval J, Courvalin P
Abstract excerpt
We have analyzed by gene amplification and sequencing mutations in the quinolone resistance-determining regions of the gyrA, gyrB, and parC genes of fluoroquinolone-resistant Streptococcus pneumoniae mutants obtained during therapy or in vitro. Mutations leading to substitutions in ParC were dete...
Topics
- Amino Acid Sequence
- Anti-Infective Agents
- DNA Gyrase
- DNA Topoisomerase IV
- DNA Topoisomerases, Type II
- DNA, Bacterial
- Drug Resistance, Microbial
- Fluoroquinolones
- Genes, Bacterial
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Pneumococcal Infections