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Article

Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro.

Antimicrobial agents and chemotherapy - 1 Nov 1996

Tankovic J, Perichon B, Duval J, Courvalin P

Abstract excerpt

We have analyzed by gene amplification and sequencing mutations in the quinolone resistance-determining regions of the gyrA, gyrB, and parC genes of fluoroquinolone-resistant Streptococcus pneumoniae mutants obtained during therapy or in vitro. Mutations leading to substitutions in ParC were detected in the two mutants obtained in vivo, BM4203-R (substitution of a histidine for an aspartate at position 84...

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Identifiers

PMID: 8913454
DOI: 10.1128/AAC.40.11.2505
PMCID: PMC163565

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Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro.PMID 8913454Read ↗

High-level fluoroquinolone resistance in Streptococcus pneumoniae requires mutations in parC and gyrA.Semantic proximity Read ↗

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