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Article

Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance.

Antimicrobial agents and chemotherapy - 1 Nov 2000

Bast D J, Low D E, Duncan C L, Kilburn L, Mandell L A, Davidson R J, de Azavedo J C

Abstract excerpt

We report on amino acid substitutions in the quinolone resistance-determining region of type II topisomerases and the prevalence of reserpine-inhibited efflux for 70 clinical isolates of S. pneumoniae for which the ciprofloxacin MIC is >/=4 microgram/ml and 28 isolates for which the ciprofloxacin MIC is </=2 microgram/ml. The amino acid substitutions in ParC conferring low-level resistance (MICs, 4 to 8...

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Identifiers

PMID: 11036021
DOI: 10.1128/AAC.44.11.3049-3054.2000
PMCID: PMC101601

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Source receipt: pubmed, retrieved 7 Sept 2026.

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