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Article

Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.

Journal of virology - 1 Mar 1996

Dunant N M, Senften M, Ballmer-Hofer K

Abstract excerpt

Middle-T antigen of mouse polyomavirus, an oncogenic DNA virus, associates with and activates the cellular tyrosine kinases c-Src, c-Yes, and Fyn. This interaction is essential for polyomavirus-mediated transformation of cells in culture and tumor formation in animals. To determine the domain of c-Src directing association with middle-T, mutant c-Src proteins lacking the amino-terminal unique domain and the...

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Identifiers

PMID: 8627648
DOI: 10.1128/JVI.70.3.1323-1330.1996
PMCID: PMC189951

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