Article
Apolipoprotein E e4 allele frequency in patients with multiple system atrophy.
Neuroscience letters - 17 Jan 1997
Cairns N J, Atkinson P F, Kovács T, Lees A J, Daniel S E, Lantos P L
Abstract excerpt
The glial cytoplasmic inclusion provides a histological hallmark for multiple system atrophy, a group of neurodegenerative disorders including: striatonigral degeneration, olivopontocerebellar atrophy, and Shy-Drager syndrome. Apolipoprotein E (APOE) genotype was determined by the polymerase chain reaction and restriction digestion of DNA extracted from frozen brain tissue from 22 patients (64.9 +/- 2.2 years)...
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