Multiple system atrophy and apolipoprotein E.

doi:10.1002/mds.27297

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Article

Multiple system atrophy and apolipoprotein E.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2018

Ogaki Kotaro, Martens Yuka A, Heckman Michael G, Koga Shunsuke, Labbé Catherine, Lorenzo-Betancor Oswaldo, Wernick Anna I, Walton Ronald L, Soto Alexandra I, Vargas Emily R, Nielsen Henrietta M, Fujioka Shinsuke, Kanekiyo Takahisa, Uitti Ryan J, van Gerpen Jay A, Cheshire William P, Wszolek Zbigniew K, Low Phillip A, Singer Wolfgang, Dickson Dennis W, Bu Guojun, Ross Owen A

Abstract excerpt

BACKGROUND: Dysregulation of the specialized lipid metabolism involved in myelin synthesis and maintenance by oligodendrocytes has been associated with the unique neuropathology of MSA. We hypothesized that apolipoprotein E, which is associated with neurodegeneration, may also play a role in the pathogenesis of MSA. OBJECTIVE: This study evaluated genetic associations of Apolipoprotein E alleles with risk of MSA...

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Identifiers

PMID: 29442376
DOI: 10.1002/mds.27297
PMCID: PMC5889322

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