Article
Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy.
Neurology - 1 Sept 1995
Tabaton M, Rolleri M, Masturzo P, Cammarata S, Angelini G, Hansen L A, Saitoh T, Petersen R B, Perry G, Richey P
Abstract excerpt
We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This...
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