The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

doi:10.1016/j.neurobiolaging.2016.10.002

Article

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

Neurobiology of aging - 1 Jan 2017

Gan-Or Ziv, Montplaisir Jacques Y, Ross Jay P, Poirier Judes, Warby Simon C, Arnulf Isabelle, Strong Stephanie, Dauvilliers Yves, Leblond Claire S, Hu Michele T M, Högl Birgit, Stefani Ambra, Monaca Christelle Charley, De Cock Valérie Cochen, Boivin Michel, Ferini-Strambi Luigi, Plazzi Giuseppe, Antelmi Elena, Young Peter, Heidbreder Anna, Barber Thomas R, Evetts Samuel G, Rolinski Michal, Dion Patrick A, Desautels Alex, Gagnon Jean-François, Dupré Nicolas, Postuma Ronald B, Rouleau Guy A

Abstract excerpt

The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14...

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The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

Abstract excerpt

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