Article
Direct antidiabetic effect of leptin through triglyceride depletion of tissues.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 1997
Shimabukuro M, Koyama K, Chen G, Wang M Y, Trieu F, Lee Y, Newgard C B, Unger R H
Abstract excerpt
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those...
Topics
- 3-Hydroxybutyric Acid
- Animals
- Carrier Proteins
- Culture Techniques
- Diabetes Mellitus, Experimental
- Esterification
- Fatty Acids, Nonesterified
- Genotype
- Hydroxybutyrates
- Hypoglycemic Agents
- Islets of Langerhans
- Leptin
- Liver
- Male
- Muscle, Skeletal