Article
Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis.
The Journal of biological chemistry - 9 May 2008
Reid Brendan N, Ables Gene P, Otlivanchik Oleg A, Schoiswohl Gabriele, Zechner Rudolf, Blaner William S, Goldberg Ira J, Schwabe Robert F, Chua Streamson C, Huang Li-Shin
Abstract excerpt
Hepatic steatosis is often associated with insulin resistance and obesity and can lead to steatohepatitis and cirrhosis. In this study, we have demonstrated that hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL), two enzymes critical for lipolysis in adipose tissues, also contribute to lipolysis in the liver and can mobilize hepatic triglycerides in vivo and in vitro. Adenoviral overexpression...
Topics
- 3-Hydroxybutyric Acid
- Adipose Tissue
- Animals
- Apolipoproteins B
- Carboxylic Ester Hydrolases
- Cell Line
- Fasting
- Fatty Acids, Nonesterified
- Fatty Liver