Article
Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia.
The Journal of biological chemistry - 23 Feb 2001
Lee Y, Wang M Y, Kakuma T, Wang Z W, Babcock E, McCorkle K, Higa M, Zhou Y T, Unger R H
Abstract excerpt
To test the hypothesis that the physiologic liporegulatory role of hyperleptinemia is to prevent steatosis during caloric excess, we induced obesity by feeding normal Harlan Sprague-Dawley rats a 60% fat diet. Hyperleptinemia began within 24 h and increased progressively to 26 ng/ml after 10 weeks, correlating with an approximately 150-fold increase in body fat (r = 0.91, p < 0.0001). During this time, the...
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